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KMID : 0363320060270030629
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 3 p.629 ~ p.638
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Effects of Water Extract of Sobokchuko-tang on Rat Blood Vessels
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Jung Yong-Sik
Kwon Jung-Nam
Min Sung-Soon
Kim Jong-Deuk
Lee Sang-Hee
Kim Jae-Kyu
Heo Jeong-Eun
Kim Young-Kyun
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Abstract
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This study was carried out to examine the relaxational response to the water extract of Sobokchuko-tang (SCT) in rat thoracic aorta. Segments of thoracic aorta obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph. It was found that the thoracic aorta segments responded to the SCT with dose-dependent vasorelaxation. At phenylephrine-induced contraction, the contractile response of thoracic aortic rings were inhibited by 99.2%. 75.3%. 42.4% and 35.8% after addition of the respective concentration (1O. 30. 100. /ml) of SCT. This vasorelaxation of rat thoracic aorta was endothelium-dependent. The action mechanisms of vasorelaxation are thought to be concerned with the role of NO. cAMP and cyclooxygenase. but not with cGMP.
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KEYWORD
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